Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stress

Stress

When a force is applied on a body, it undergoes deformation. In order to restore the body to its original shape and/or size, an opposite or restoring force is generated within the body. This restoring force is equal to the magnitude of the applied force, but acts in the opposite direction. The amount of this restoring force developed per unit area of the body is called stress. Stress is a tensor quantity and has the SI unit pascal. Stress can be separated into four broad categories depending...

Stress Response System

Stress Response System

The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's initial...

Stress: General Loading Conditions

Stress: General Loading Conditions

To grasp the intricacy of real-world conditions where multiple loads are applied simultaneously to a structure, one might visualize a section passing through a specific point within a body, aligned parallel to the xy plane. This section is subjected to various forces, including original loads, normal forces, and shearing forces.
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes.

General State of Stress

General State of Stress

The general state of stress within a material can be accurately depicted using a stress tensor. This tensor encapsulates the internal forces distributed within a material subjected to external forces or deformations.
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...

Stress Concentrations

Stress Concentrations

The concept of stress concentration is crucial for understanding how materials respond under bending stresses, particularly when there are irregularities or discontinuities in the material's geometry. Normally, stress in a symmetric member subjected to pure bending is assumed to be uniformly distributed across the entire cross-section. However, this assumption does not hold when there are variations in the cross-sectional geometry or the presence of notches and holes.
The stress concentration...

Stress Concentrations

Stress Concentrations

Stress concentration is when stress intensifies near discontinuities such as holes or abrupt cross-sectional changes in a structural member. This localized stress can often surpass the average stress within the member. The stress distribution in flat bars, either with a circular hole or varying widths connected by fillets, can be determined experimentally using a photoelastic method. The results are based on ratios of geometric parameters like the ratio of the hole's radius to the smaller width...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Production and Purification of Recombinant SUMOylation Enzymes and SUMO Proteins.

Methods in molecular biology (Clifton, N.J.)·2025

Same author

Targeting SUMOylation Triggers IFN-β-dependent Activation of Patient and Allogenic NK Cells in Preclinical Models of Acute Myeloid Leukemia.

Molecular cancer therapeutics·2025

Same author

Generation of non-genetically modified, CAR-like, NK cells.

Journal for immunotherapy of cancer·2024

Same author

SUMOylation inhibitor TAK-981 (subasumstat) synergizes with 5-azacytidine in preclinical models of acute myeloid leukemia.

Haematologica·2023

Same author

DeSUMOylation of chromatin-bound proteins limits the rapid transcriptional reprogramming induced by daunorubicin in acute myeloid leukemias.

Nucleic acids research·2023

Same author

Multiple Fra-1-bound enhancers showing different molecular and functional features can cooperate to repress gene transcription.

Cell & bioscience·2023

Search research articles

Related Experiment Video

Updated: Jul 1, 2026

Chronic Unpredictable Mild Stress in Rats based on the Mongolian medicine

Chronic Unpredictable Mild Stress in Rats based on the Mongolian medicine

Published on: October 27, 2023

SUMO under stress.

Denis Tempé¹, Marc Piechaczyk, Guillaume Bossis

¹Institut de Génétique Moléculaire de Montpellier, CNRS, UMR 5535, IFR 122, 1919 Route de Mende, Montpellier F-34293, France.

Biochemical Society Transactions

|September 17, 2008

Summary

This summary is machine-generated.

Environmental stresses regulate protein SUMOylation (small ubiquitin-related modifier) through direct target modification or by altering the SUMOylation machinery. This review explores these stress-SUMOylation connections and their cellular impacts.

More Related Videos

Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice

Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice

Published on: January 7, 2019

Measurements of Physiological Stress Responses in C. Elegans

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

Related Experiment Videos

Last Updated: Jul 1, 2026

Chronic Unpredictable Mild Stress in Rats based on the Mongolian medicine

Chronic Unpredictable Mild Stress in Rats based on the Mongolian medicine

Published on: October 27, 2023

Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice

Evaluating the Anti-depression Effect of Xiaoyaosan on Chronically-stressed Mice

Published on: January 7, 2019

Measurements of Physiological Stress Responses in C. Elegans

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

Area of Science:

Biochemistry
Molecular Biology
Cellular Stress Response

Background:

SUMOylation (small ubiquitin-related modifier) is a key post-translational modification regulating protein function and fate.
The precise regulation of SUMOylation itself, particularly under stress conditions, remains an area of active investigation.

Purpose of the Study:

To review the current understanding of how environmental stresses influence SUMOylation.
To elucidate the molecular mechanisms linking stress and SUMOylation.
To discuss the consequences of these interactions on cellular functions.

Main Methods:

Literature review of studies investigating SUMOylation and cellular stress responses.
Analysis of molecular mechanisms involving stress-induced phosphorylation and SUMOylation.
Examination of changes in SUMOylation machinery under various stress conditions.

Main Results:

Environmental stresses (osmotic, hypoxic, heat, oxidative, genotoxic) significantly impact the SUMOylation/deSUMOylation balance.
Regulation occurs via direct interplay with stress-induced phosphorylation or by modulating SUMOylation enzyme activity/abundance.
These regulatory events affect the fate and function of numerous cellular proteins.

Conclusions:

SUMOylation is a critical node in cellular stress response pathways.
Understanding stress-induced SUMOylation regulation provides insights into cellular adaptation and disease.
Further research into the stress-SUMOylation axis is essential for comprehending cellular resilience.