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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

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Published on: January 28, 2020

Circulating serum adiponectin levels in patients with coronary artery disease: relationship to atherosclerotic burden

J V Patel1, A Abraheem, O Dotsenko

  • 1Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK.

Journal of Internal Medicine
|September 17, 2008
PubMed

Insights

Plasma adiponectin levels decrease with coronary artery disease (CAD) severity, independent of cardiac function. Triglycerides and age influence adiponectin, suggesting prognostic utility in CAD patients.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Biomarkers

Background:

  • Adipocyte function impacts coronary heart disease (CHD) and cardiac function, with adiponectin as a potential link.
  • The role of adiponectin in discriminating CHD severity, potentially confounded by cardiac function, remains unclear.
  • This study investigated the relationship between plasma adiponectin and coronary artery disease (CAD) severity.

Purpose of the Study:

  • To determine if plasma adiponectin levels correlate with coronary artery disease severity.
  • To assess the association between adiponectin and cardiac function indices like ejection fraction (EF) and regional wall motion abnormalities (RWMA).
  • To identify independent predictors of adiponectin levels in patients with CAD.

Main Methods:

  • A cross-sectional study measured plasma adiponectin using ELISA in 204 patients undergoing coronary angiography.
  • Coronary artery disease severity was assessed using coronary atheroma scores (CAS).
  • Cardiac function was evaluated by ejection fraction (EF) and regional wall motion abnormalities (RWMA).

Main Results:

  • Adiponectin levels showed a significant inverse relationship with increasing CAS tertiles (P=0.047) but not absolute CAS values (P=0.06).
  • Adiponectin levels were not significantly correlated with EF or RWMA.
  • Multivariate analysis revealed adiponectin was independently inversely associated with triglycerides and CAS tertiles, and positively with age.

Conclusions:

  • Plasma adiponectin levels decrease with increasing coronary artery disease severity, irrespective of systolic dysfunction.
  • Adiponectin levels are influenced by established CHD risk factors, including triglycerides and age.
  • Further research is needed to establish the clinical prognostic value of adiponectin in patients with coronary heart disease.
Abstract

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