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Isolated ventricular noncompaction in patients with chronic renal failure
N S Markovic1, N Dimkovic, T Damjanovic
1Cardiology Department, Zvezdara University Medical Center, Belgrade, Serbia. natmarkovic@yahoo.com
Clinical Nephrology
|September 17, 2008
Summary
Isolated ventricular noncompaction, a rare heart condition, was observed in two patients with chronic renal failure. Early diagnosis through regular echocardiography is crucial for managing this severe cardiac abnormality.
Area of Science:
- Cardiology
- Nephrology
- Genetics
Background:
- Isolated ventricular noncompaction (IVNC) is a rare congenital cardiac disorder with a poor prognosis.
- Chronic renal failure (CRF) is associated with various cardiovascular complications.
- The co-occurrence of IVNC and CRF is infrequently reported.
Observation:
- Two cases of IVNC in patients with CRF are presented.
- Case 1: A 65-year-old male on hemodialysis for 3.5 years with mesangioproliferative glomerulonephritis.
- Case 2: A patient with CRF due to renal calculosis, admitted for non-ST elevation acute myocardial infarction.
Findings:
- Echocardiography revealed enlarged left ventricles with thickened, bilayered walls (compacted epicardial layer, noncompaction endocardial layer).
- Left ventricular cavity to recess blood flow was confirmed by Color Doppler.
- Patients exhibited arrhythmias: intermittent right bundle branch block (Case 1) and premature ventricular contractions (Case 2).
Implications:
- This highlights the importance of regular echocardiographic screening in CRF patients to detect cardiovascular comorbidities like IVNC.
- Early diagnosis and management, including anticoagulation, may improve outcomes for patients with IVNC and CRF.
- Further research is needed to understand the relationship between CRF and IVNC and its genetic underpinnings.
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