Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation

Liselotte Bäckdahl1, Andrew Bushell, Stephan Beck

  • 1Medical Genomics Group, UCL Cancer Institute, University College London, London WC1E 6BT, UK. l.backdahl@ucl.ac.uk

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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Acute Inflammation I: Inflammatory Response

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