Related Experiment Video
Updated: Jul 1, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
Inflammatory signalling as mediator of epigenetic modulation in tissue-specific chronic inflammation
Liselotte Bäckdahl1, Andrew Bushell, Stephan Beck
1Medical Genomics Group, UCL Cancer Institute, University College London, London WC1E 6BT, UK. l.backdahl@ucl.ac.uk
Abstract:
Recent successes of therapeutic intervention in chronic inflammatory diseases using epigenetic modifiers such as histone deacetylase inhibitors and inhibitors of DNA methylation suggest that epigenetic reprogramming plays a role in the aetiology of these diseases. The epigenetic signature of a given immune cell is reflected in the history of modifications from different signals the cell has been subjected to during differentiation. Like other cells, differentiating immune cells are dependent on a complex combination of inter- and intracell signalling as well as transcription machineries to modulate their epigenomes in order to mediate differentiation. Despite extensive research into these processes, the link between cellular signalling and epigenetic modulation remains poorly understood. Here, we review recent progress and discuss key factors driving epigenetic modulation in chronic inflammation.
Related Concept Videos
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Chronic Inflammation: Introduction
Inflammatory Bowel Disease III: Crohn's Disease
Acute Inflammation I: Inflammatory Response
Acute Inflammation III: Local and Systemic Effects
Epigenetic Regulation