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Phases of Wound Repair

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Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
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Related Experiment Video

Updated: Jul 1, 2026

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

Published on: December 27, 2024

Topical advances in wound care.

Alexander Stojadinovic¹, Jay W Carlson, Gregory S Schultz

¹Department of Surgery, Division of Surgical Oncology, Walter Reed Army Medical Center, Washington, D.C., USA. alexander.stojadinovic@amedd.army.mil

Gynecologic Oncology

|September 17, 2008

Summary

Chronic wounds fail to heal due to factors like ischemia and bacterial contamination. Effective wound bed preparation using the TIME principle optimizes healing and topical therapies.

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Last Updated: Jul 1, 2026

Chessboard-like Burn Wound Healing Model of Mice Based on Digital Heating Device

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Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

Published on: May 2, 2025

Area of Science:

Wound Healing
Tissue Repair
Regenerative Medicine

Background:

Acute wounds heal effectively, while chronic wounds present significant challenges.
Chronic wounds result from multifactorial issues including ischemia, necrosis, impaired host response, and bacterial contamination.
Bacterial burden sustains inflammation, halting wound healing progression.

Purpose of the Study:

To summarize a systematic approach to wound bed preparation.
To highlight the "TIME" principle for optimizing wound healing.
To discuss advances in topical wound care.

Main Methods:

Systematic review of wound healing literature.
Application of the TIME (Tissue, Infection/Inflammation, Moisture, Edge) principle.
Analysis of current topical wound care strategies.

Main Results:

Chronic wounds are characterized by persistent local and systemic barriers to healing.
The TIME principle provides a framework for addressing these barriers.
Optimizing the wound environment through preparation is crucial for healing.

Conclusions:

Wound bed preparation is essential for managing chronic wounds.
The TIME principle offers a structured approach to wound management.
Advances in topical therapies enhance the efficacy of wound bed preparation.