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Updated: Jul 1, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and biological evaluation of alkoxycoumarins as novel nematicidal constituents
Kazuto Takaishi1, Minoru Izumi, Naomichi Baba
1Laboratory of Applied Natural Products Chemistry, The Graduate School of Natural Science and Technology, Okayama University, 1-1-1 Tsushimanaka, Okayama, Okayama 700-8530, Japan. ktakaishi@riken.jp
Abstract:
We synthesized all of the monomethoxycoumarins, 5-alkoxycoumarins and their derivatives, and investigated their nematicidal activity against the phytopathogenic nematode, Bursaphelenchus xylophilus. Among the compounds, 5-ethoxycoumarin showed the highest nematicidal activity. Furthermore, 5-ethoxycoumarin was comparatively harmless against both the brine shrimps, Artemia salina, and the Japanese killifish, Oryzias latipes.
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