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Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue
12:40

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue

Published on: June 6, 2016

The retained placenta.

Andrew D Weeks1

  • 1School of Reproductive and Developmental Medicine, Liverpool Women's Hospital, Crown Street, Liverpool L8 7SS, UK. aweeks@liverpool.ac.uk

Best Practice & Research. Clinical Obstetrics & Gynaecology
|September 17, 2008
PubMed
Summary
This summary is machine-generated.

Retained placenta (RP) management varies globally. Manual removal is common, but intraumbilical oxytocin can reduce its need by 20%.

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Area of Science:

  • Obstetrics and Gynecology
  • Maternal Health
  • Postpartum Care

Background:

  • Retained placenta (RP) incidence and outcomes differ significantly worldwide.
  • In developing nations, RP affects 0.1% of births with a 10% fatality rate.
  • In developed countries, RP occurs in 3% of vaginal deliveries with rare mortality.

Purpose of the Study:

  • To outline the types, management, and prevention strategies for retained placenta.
  • To highlight the global disparities in retained placenta incidence and case fatality rates.

Main Methods:

  • Review of retained placenta types: placenta adherens, trapped placenta, and partial accreta.
  • Discussion of treatment options: manual removal of placenta (30-60 minutes postpartum), medical management, and pharmacological interventions.
  • Exploration of preventative measures, including intraumbilical oxytocin and glyceryl trinitrate for trapped placenta.

Main Results:

  • Manual removal of placenta is a primary treatment for all RP types.
  • Intraumbilical oxytocin (30 i.u. in 30 mL saline) can decrease the need for manual removal by 20%.
  • Glyceryl trinitrate or controlled cord traction may resolve trapped placenta.

Conclusions:

  • Effective management of retained placenta requires understanding its types and available treatments.
  • Preventative strategies like intraumbilical oxytocin can significantly reduce intervention rates.
  • Addressing global disparities in RP outcomes remains a critical public health concern.