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Thrombocytosis associated with malignant ovarian lesions within a pediatric/adolescent population
1Division of Gynecology, Department of Surgery, Children's Hospital Boston, Boston, Massachusetts 02115, USA.
Study Objective:
To determine if there is an association between pediatric ovarian malignancies and elevated platelet counts:
Design:
Retrospective chart review.
Setting:
Large referral children's hospital.
Participants:
154 patients taken to the operating room between February 1993 and February 2006 with an adnexal mass where ovarian tissue was submitted for pathological analysis.
Main Outcome Measures:
The principle outcome was the presence of ovarian malignancy.
Results:
We found that there is an increase in thrombocytosis among individuals with ovarian malignancy, with as high as 33% of those with ovarian germ cell tumors demonstrating preoperative thrombocytosis.
Conclusion:
These results suggest that thrombocytosis may be a useful marker for ovarian malignancy in this population. Further studies will be needed to determine if there is any prognostic value to thrombocytosis among these patients, with a potential value for counseling and future intervention based on these findings.
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