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The Translational Research Working Group developmental pathway for anticancer agents (drugs or biologics)

Richard L Schilsky1, Gary Gordon, Tona M Gilmer

  • 1University of Chicago, Chicago, Illinois, USA.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|September 17, 2008
PubMed

Insights

The Translational Research Working Group (TRWG) developed an Agents Developmental Pathway to advance cancer treatments. This framework aids in moving therapeutic agents from discovery to clinical trials, addressing key challenges in cancer research.

Area of Science:

  • Oncology
  • Translational Research
  • Drug Development

Background:

  • The National Cancer Institute established the Translational Research Working Group (TRWG) to assess and shape its investment in translational research.
  • Translational research is crucial for bridging laboratory discoveries with clinical applications in cancer treatment.

Purpose of the Study:

  • To present the Agents Developmental Pathway, a key component of the TRWG's conceptualization of translational research.
  • To outline the processes involved in developing therapeutic agents for cancer treatment and prevention.

Main Methods:

  • Conceptualization of translational research as six developmental pathways.
  • Focus on the Agents Developmental Pathway, detailing the progression of small molecules and biologics.
  • Identification of critical challenges within the agent development process.

Main Results:

  • The TRWG defined translational research pathways, including one for agent development.
  • The Agents Developmental Pathway serves as a tool to streamline the progression of therapeutic agents.
  • Key challenges in agent development were identified and discussed.

Conclusions:

  • The Agents Developmental Pathway provides a structured approach to cancer agent development.
  • Addressing identified challenges is essential for efficient translation of cancer therapies.
  • This pathway facilitates the movement of agents toward definitive clinical testing.

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