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Related Experiment Video

Updated: Jul 1, 2026

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Translational Research Working Group developmental pathway for immune response modifiers.

Martin A Cheever¹, Jeffrey Schlom, Louis M Weiner

¹Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research

|September 17, 2008

Summary

This summary is machine-generated.

The Translational Research Working Group (TRWG) evaluated National Cancer Institute

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Last Updated: Jul 1, 2026

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using Poly(I:C) to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Generation of Immature, Mature and Tolerogenic Dendritic Cells with Differing Metabolic Phenotypes

Published on: June 22, 2016

Area of Science:

Oncology
Translational Research
Immunotherapy

Background:

The National Cancer Institute (NCI) established the Translational Research Working Group (TRWG) to assess current investments and future directions in translational cancer research.
Translational research aims to bridge the gap between laboratory discoveries and clinical applications.
The TRWG identified six key developmental pathways within translational research.

Purpose of the Study:

To evaluate the NCI's investment in translational research.
To conceptualize the future of translational research.
To discuss challenges in developing immune response modifiers within a defined pathway.

Main Methods:

The TRWG conceptualized translational research as a series of developmental pathways.
One pathway focuses on the development of immune response modifiers (e.g., vaccines, cytokines).
This pathway serves as a tool to guide candidate assays toward clinical testing.

Main Results:

The Immune Response Modifier Developmental Pathway emphasizes coordinated development of multiple components.
This pathway is a conceptual model, not an exhaustive depiction of real-world processes.
The paper examines challenges in immune response modifier agent development using this pathway framework.

Conclusions:

The Immune Response Modifier Pathway provides a structured approach for advancing immunotherapies.
Coordinated development is crucial for successful immune response modifier agents.
Addressing key challenges within this pathway is essential for efficient clinical translation.