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Updated: Jul 1, 2026

The Subventricular Zone En-face: Wholemount Staining and Ependymal Flow
Published on: May 6, 2010
The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone
Hai-Kun Liu1, Thorsten Belz, Dagmar Bock
1Division of Molecular Biology of the Cell I, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany.
Abstract:
The tailless (Tlx) gene encodes an orphan nuclear receptor that is expressed by neural stem/progenitor cells in the adult brain of the subventricular zone (SVZ) and the dentate gyrus (DG). The function of Tlx in neural stem cells of the adult SVZ remains largely unknown. We show here that in the SVZ of the adult brain Tlx is exclusively expressed in astrocyte-like B cells. An inducible mutation of the Tlx gene in the adult brain leads to complete loss of SVZ neurogenesis. Furthermore, analysis indicates that Tlx is required for the transition from radial glial cells to astrocyte-like neural stem cells. These findings demonstrate the crucial role of Tlx in the generation and maintenance of NSCs in the adult SVZ in vivo.
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