Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

Differentiation of Common Myeloid Progenitor Cells

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Measurement uncertainty in three sample glomerular filtration rate tests.

Nuclear medicine communications·2026

Same author

Estimating the realised economic value of a historic Mediterranean fruit fly eradication.

Scientific reports·2025

Same author

Global warming reduces the carrying capacity of the tallest angiosperm species (Eucalyptus regnans).

Nature communications·2025

Same author

Establishing measurement traceability for quantitative SPECT imaging.

EJNMMI physics·2025

Same author

Exacerbation of Hepatic Damage in Endothelial Aquaporin 1 Transgenic Mice after Experimental Heatstroke.

Biomedicines·2024

Same author

Adaptive sampling method to monitor low-risk pathways with limited surveillance resources.

Risk analysis : an official publication of the Society for Risk Analysis·2024

Search research articles

Related Experiment Video

Updated: Jul 1, 2026

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Published on: April 15, 2014

Stem/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of

Hirokazu Ohtaki¹, Joni H Ylostalo, Jessica E Foraker

¹Center for Gene Therapy, Tulane University Health Sciences Center, New Orleans, LA 70112, USA.

Proceedings of the National Academy of Sciences of the United States of America

|September 17, 2008

Summary

Human mesenchymal stromal cells (hMSCs) improved neurological function and reduced brain cell death after ischemia. These cells modulated inflammatory and immune responses, promoting healing.

More Related Videos

Hypoxic Preconditioning of Marrow-derived Progenitor Cells As a Source for the Generation of Mature Schwann Cells

Hypoxic Preconditioning of Marrow-derived Progenitor Cells As a Source for the Generation of Mature Schwann Cells

Published on: June 14, 2017

Adipose-Derived Mesenchymal Stromal Cells Co-Cultured with Primary Mixed Glia to Reduce Prion-Induced Inflammation

Adipose-Derived Mesenchymal Stromal Cells Co-Cultured with Primary Mixed Glia to Reduce Prion-Induced Inflammation

Published on: August 11, 2023

Related Experiment Videos

Last Updated: Jul 1, 2026

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Systemic Injection of Neural Stem/Progenitor Cells in Mice with Chronic EAE

Published on: April 15, 2014

Hypoxic Preconditioning of Marrow-derived Progenitor Cells As a Source for the Generation of Mature Schwann Cells

Hypoxic Preconditioning of Marrow-derived Progenitor Cells As a Source for the Generation of Mature Schwann Cells

Published on: June 14, 2017

Adipose-Derived Mesenchymal Stromal Cells Co-Cultured with Primary Mixed Glia to Reduce Prion-Induced Inflammation

Adipose-Derived Mesenchymal Stromal Cells Co-Cultured with Primary Mixed Glia to Reduce Prion-Induced Inflammation

Published on: August 11, 2023

Area of Science:

Neuroscience
Immunology
Regenerative Medicine

Background:

Transient global ischemia causes significant neuronal cell death in the hippocampus.
Inflammatory and immune responses play a critical role in post-ischemic brain injury.

Purpose of the Study:

To investigate the therapeutic effects of human mesenchymal stromal cells (hMSCs) in a mouse model of transient global ischemia.
To elucidate the underlying mechanisms of hMSC-mediated neuroprotection, focusing on immune and inflammatory modulation.

Main Methods:

hMSCs were injected into the hippocampus of adult mice 1 day after inducing transient global ischemia.
Neurologic function and neuronal cell death were assessed.
Microarray assays were performed to analyze gene expression changes in the mouse brain and hMSCs.
Protein expression in hippocampal microglia/macrophages was analyzed.

Main Results:

hMSCs treatment improved neurologic function and decreased hippocampal neuronal cell death.
hMSCs persisted for less than 7 days but modulated ischemia-induced gene expression, particularly down-regulating inflammatory and immune response genes.
hMSCs up-regulated neuroprotective genes like Ym1 in the host brain.
Protein analysis revealed increased expression of Ym1, insulin-like growth factor 1, galectin-3, type 2 immune bias cytokines, and MHC II in microglia/macrophages.

Conclusions:

hMSCs exert neuroprotective effects following transient global ischemia.
The beneficial effects are primarily mediated by the modulation of inflammatory and immune responses, likely through alternative activation of microglia and macrophages.