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Aurora kinases: structure, functions and their association with cancer

Madhu Kollareddy1, Petr Dzubak, Daniella Zheleva

  • 1Laboratory of Experimental Medicine, Department of Pediatrics, Faculty of Medicine, Palacky University, Olomouc, Czech Republic.

Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
|September 17, 2008
PubMed
Abstract

Insights

Aurora kinases regulate cell division and are implicated in cancer. Inhibitors targeting these kinases show promise for effective cancer therapy, making them key targets for drug development.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Aurora kinases (A, B, C) are serine/threonine protein kinases crucial for mitosis.
  • Their functions include spindle assembly, centrosome and cytoskeleton regulation, and cytokinesis.
  • Aberrant Aurora kinase expression is linked to cancer development.

Purpose of the Study:

  • To review the biology of Aurora kinases, including their structure, function, and regulation.
  • To explore the association between Aurora kinases and cancer.
  • To discuss their potential as therapeutic targets in oncology.

Main Methods:

  • A comprehensive literature search was conducted.
  • Key studies on Aurora kinase biology and cancer association were analyzed.

Main Results:

  • Aurora kinases play essential roles in multiple mitotic events.
  • Dysregulation of Aurora kinases contributes to uncontrolled cell division and tumorigenesis.
  • Existing Aurora kinase inhibitors have demonstrated efficacy across various tumor types.

Conclusions:

  • Aurora kinases are vital regulators of cell division and significant targets for cancer treatment.
  • Clinical data for Aurora kinase inhibitors are promising, supporting further development.
  • Novel Aurora kinase inhibitors offer potential for targeted cancer therapies.

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