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The diabetogenic and acidotropic effects of chelators
E D Goldberg1, V A Eshchenko, V D Bovt
1Tomsk Scientific Center, U.S.S.R. Academy of Medical Sciences.
Experimental Pathology
|January 1, 1991
Abstract:
Diabetogenic and acidotropic effects of dithizone, 8-(p-toluenesulfonylamino)-quinoline and 8-(benzenesulfonylamino)-quinoline were studied in experiments on cats, rabbits, golden hamsters and mice. Selective damage of insulin producing cells, phase glycemic fluctuations and permanent diabetes development were shown to be connected with chelator zinc binding in the lysosome-segregation apparatus of these cells.