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Thyroid hormone increases glyceraldehyde 3-phosphate dehydrogenase gene expression in rat liver
1Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa 33612.
FEBS Letters
|August 19, 1991
Abstract:
Livers from hypophysectomized rats had low levels of glyceraldehyde 3-phosphate dehydrogenase mRNA. Administration of L-triiodothyronine increased these levels over 20-fold. The peak response was seen 72 h after hormone administration. A half-maximal response was obtained with 5 micrograms of T3 per 100 g of body weight. Thus the expression of hepatic glyceraldehyde 3-phosphate dehydrogenase appears to be regulated by thyroid hormone.