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Related Experiment Videos

Oxygen-induced changes in hemoglobin expression in Drosophila.

Eva Gleixner1, Daniela Abriss, Boris Adryan

  • 1Institute of Molecular Genetics, University of Mainz, Germany.

The FEBS Journal
|September 18, 2008
PubMed
Summary

Fruit fly hemoglobin (dmeglob1) expression decreases with hypoxia but increases with reoxygenation or hyperoxia. This suggests dmeglob1 may protect against excess oxygen, not just store it.

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Area of Science:

  • * Molecular Biology
  • * Environmental Physiology
  • * Drosophila melanogaster Research

Background:

  • * The hemoglobin gene 1 (dmeglob1) in Drosophila melanogaster is found in the tracheal system and fat body.
  • * dmeglob1 has been previously linked to hypoxia resistance in fruit flies.

Purpose of the Study:

  • * To investigate the expression patterns of dmeglob1 and lactate dehydrogenase (LDH) under varying oxygen conditions (hypoxia and hyperoxia).
  • * To elucidate the functional role of dmeglob1 in fruit flies under different oxygen tensions.

Main Methods:

  • * Quantitative analysis of dmeglob1 and LDH mRNA levels in Drosophila embryos, larvae, and adults.
  • * Exposure of fruit flies to controlled hypoxic (low O2) and hyperoxic (high O2) environments.

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  • * Application of hypoxia/reoxygenation stress to third instar larvae.

    • Main Results:

    • * Lactate dehydrogenase mRNA levels increased under hypoxia, as anticipated.
    • * dmeglob1 mRNA levels decreased under both short-term and long-term hypoxia compared to normoxic controls.
    • * A hypoxia/reoxygenation cycle and hyperoxia both led to elevated dmeglob1 mRNA levels.

    Conclusions:

    • * The expression profile of dmeglob1 under varying oxygen conditions challenges its role as a simple O2 storage protein.
    • * dmeglob1 may play a protective role against hyperoxia by regulating O2 flux or mitigating reactive oxygen species damage.