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Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
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Kidney function and cognitive performance and decline in older men.

Yelena Slinin1, Misti L Paudel, Areef Ishani

  • 1Center for Chronic Disease Outcomes Research, Veterans Affairs Medical Center, Minneapolis, Minnesota, USA. slini001@umn.edu

Journal of the American Geriatrics Society
|September 18, 2008
PubMed
Summary

Mild to moderate kidney function decline is linked to poorer executive function in older men. This association persisted even after accounting for other factors, suggesting a specific link between renal health and cognitive performance.

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Area of Science:

  • Gerontology
  • Nephrology
  • Neuroscience

Background:

  • Cognitive impairment and decline are significant concerns in aging populations.
  • Kidney function, measured by estimated glomerular filtration rate (eGFR), naturally declines with age.
  • The relationship between reduced kidney function and cognitive health in elderly men requires further investigation.

Purpose of the Study:

  • To investigate the association between kidney function and prevalent cognitive impairment.
  • To examine the association between kidney function and incident cognitive decline over a 5-year period in elderly men.

Main Methods:

  • An observational prospective cohort study involving 5,529 community-dwelling men aged 65 and older.
  • Kidney function assessed using estimated glomerular filtration rate (eGFR) via the MDRD equation.
  • Cognitive function evaluated using the Modified Mini-Mental State Examination (3MS) and Trail Making Test B (Trails B).

Main Results:

  • At baseline, reduced eGFR was associated with higher odds of cognitive impairment, particularly on the Trails B test.
  • Over 5 years, reduced eGFR was linked to increased risk of cognitive decline, but this association was largely explained by confounders.
  • An independent association between mild to moderate reduced kidney function and poor executive function (Trails B) was observed at baseline.

Conclusions:

  • Mild to moderate reductions in kidney function are independently associated with poorer executive function in older men.
  • The study did not find an independent association between reduced kidney function and global cognitive impairment or cognitive decline risk.
  • Findings highlight the importance of monitoring kidney function in relation to specific cognitive domains, like executive function, in elderly men.