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Updated: Jun 30, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Chemotherapy-induced peripheral neuropathy.

Bushra Malik¹, Mark Stillman

¹Section of Headache and Pain, Department of Neurology, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA.

Current Pain and Headache Reports

|September 18, 2008

Summary

Chemotherapy improves survival for cancer patients but can cause delayed nervous system damage. This neurotoxicity primarily affects the peripheral nerves, leading to chemotherapy-induced peripheral neuropathy.

Area of Science:

Oncology
Neuroscience
Pharmacology

Background:

Advances in chemotherapy have improved cancer patient survival rates.
Chemotherapy can cause significant side effects, including neurotoxicity.
Chemotherapy-induced neurotoxicity often presents with delayed onset and progressive symptoms.

Purpose of the Study:

To highlight the impact of chemotherapy on the nervous system.
To describe the mechanisms of chemotherapy-induced neurotoxicity.
To define chemotherapy-induced peripheral neuropathy.

Main Methods:

Review of recent advances in chemotherapy development and administration.
Analysis of the toxic effects of chemotherapy on the nervous system.
Focus on the peripheral nervous system's vulnerability.

Related Experiment Videos

Last Updated: Jun 30, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Main Results:

Chemotherapy leads to prolonged survival but with a risk of neurotoxicity.
Neurotoxicity is frequently delayed and progressive.
The peripheral nerve is a primary target, affecting neurons, axons, and myelin.

Conclusions:

Chemotherapy-induced neurotoxicity is a significant concern.
Peripheral neuropathy is a common manifestation of this toxicity.
Understanding these effects is crucial for patient management.