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Synthesis of nucleoside-based antiviral drugs in ionic liquids
Vineet Kumar1, Sanjay V Malhotra
1Laboratory of Synthetic Chemistry, SAIC-Frederick Inc., National Cancer Institute-Frederick, 1050 Boyles Street, Frederick, MD 21702, USA.
Bioorganic & Medicinal Chemistry Letters
|September 18, 2008
Abstract:
Nucleoside-based antiviral drugs have been synthesized using imidazolium-based ionic liquids as reaction medium. The ionic liquids were proved to be better solvents for all the nucleoside in terms of solubility and reaction medium as compared to conventional molecular solvents.