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Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...

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MonkeySNP: a web portal for non-human primate single nucleotide polymorphisms.

Samone Khouangsathiene1, Carlo Pearson, Summer Street

  • 1Oregon National Primate Research Center, Oregon Health & Science University, 505 N.W. 185th Avenue, Beaverton, OR 97006, USA.

Bioinformatics (Oxford, England)
|September 18, 2008
PubMed
Summary

MonkeySNP provides easy access to non-human primate (NHP) single nucleotide polymorphism (SNP) data. This resource mirrors NCBI dbSNP and adds valuable subpopulation genotype data for NHP research.

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Area of Science:

  • Genetics
  • Bioinformatics
  • Primate Research

Background:

  • Non-human primates (NHPs) are crucial models in biomedical research.
  • Access to genetic variation data, specifically single nucleotide polymorphisms (SNPs), is essential for NHP studies.
  • Existing databases may lack comprehensive NHP-specific data.

Purpose of the Study:

  • To create a centralized, web-based resource for accessing NHP SNP data.
  • To enhance the utility of NHP genetic data for researchers.
  • To facilitate SNP review and selection for NHP studies.

Main Methods:

  • Developed MonkeySNP as a web-based resource.
  • Mirrored the NCBI dbSNP database.
  • Integrated additional NHP subpopulation genotype data.
  • Incorporated visual genotype displays.

Main Results:

  • MonkeySNP offers a comprehensive collection of NHP SNP data.
  • The resource provides access to NHP subpopulation-specific genotypes.
  • Visual genotype displays aid in SNP analysis and selection.

Conclusions:

  • MonkeySNP significantly improves access to NHP genetic variation data.
  • The resource supports NHP research by providing detailed genotype information.
  • MonkeySNP serves as a valuable tool for geneticists and researchers utilizing NHP models.