Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
Testosterone: Functions and Regulation01:26

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...
Hormonal Control of the Ovarian Cycle01:30

Hormonal Control of the Ovarian Cycle

The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle.  At puberty, GnRH secretion increases in both frequency and...
Hormonal Regulation of the Menstrual Cycle01:22

Hormonal Regulation of the Menstrual Cycle

The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Development of the Sexual Organs in the Embryo and Fetus01:15

Development of the Sexual Organs in the Embryo and Fetus

Development of the reproductive organs in an embryo starts from a bipotential state. This means the early embryo can develop either male or female reproductive organs. The formation of these organs begins with the growth of gonadal ridges that arise from the intermediate mesoderm during the fifth week of development.
Near the gonadal ridges, two duct systems are present: the mesonephric ducts (Wolffian ducts) and paramesonephric ducts (Müllerian ducts). These ducts form the basis for the male...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intranasal monoclonal antibodies do not prevent respiratory infection in a randomized, controlled experimental infection trial.

npj drug discovery·2026
Same author

T-cell responses to primary SARS-CoV-2 vaccination in Down syndrome - From childhood to adulthood.

Human vaccines & immunotherapeutics·2026
Same author

Natural SARS-CoV-2 infection in farmed minks <i>(Neovison vison)</i> causes lung pathology, systemic viral spread, and transmission risk, even in asymptomatic animals.

Frontiers in veterinary science·2026
Same author

Distinct Effects of Autologous Hematopoietic Stem Cell Transplantation on T Cell Composition and Profile in Refractory Crohn's Disease.

Inflammatory bowel diseases·2026
Same author

Proteomic Signatures Over Age Reveal Significant Changes From Infancy Till Late Adulthood.

Advanced biology·2026
Same author

New biomarkers for the diagnosis of primary central nervous system lymphoma in CSF: A multicenter retrospective cohort study.

Neuro-oncology advances·2025

Related Experiment Video

Updated: Jun 30, 2026

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
06:38

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

Published on: October 13, 2018

Inducing puberty.

Eveline M Delemarre1, Bram Felius, Henriette A Delemarre-van de Waal

  • 1Medical School Leiden Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands.

European Journal of Endocrinology
|September 18, 2008
PubMed
Summary

Delayed puberty, often familial, can be treated with androgens or hormone therapy to stimulate growth and development. Hypogonadotropic hypogonadism, a rare condition, can be managed with pulsatile GnRH, gonadotropins, or sex steroids for fertility and secondary sex characteristics.

More Related Videos

Rodent Estrous Cycle Monitoring Utilizing Vaginal Lavage: No Such Thing As a Normal Cycle
09:05

Rodent Estrous Cycle Monitoring Utilizing Vaginal Lavage: No Such Thing As a Normal Cycle

Published on: August 30, 2021

A Modified Technique for Inducing Polycystic Ovary Syndrome in Mice
04:49

A Modified Technique for Inducing Polycystic Ovary Syndrome in Mice

Published on: July 5, 2024

Related Experiment Videos

Last Updated: Jun 30, 2026

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
06:38

Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats

Published on: October 13, 2018

Rodent Estrous Cycle Monitoring Utilizing Vaginal Lavage: No Such Thing As a Normal Cycle
09:05

Rodent Estrous Cycle Monitoring Utilizing Vaginal Lavage: No Such Thing As a Normal Cycle

Published on: August 30, 2021

A Modified Technique for Inducing Polycystic Ovary Syndrome in Mice
04:49

A Modified Technique for Inducing Polycystic Ovary Syndrome in Mice

Published on: July 5, 2024

Area of Science:

  • Reproductive Endocrinology
  • Pediatric Endocrinology

Background:

  • Puberty onset is regulated by pulsatile gonadotropin-releasing hormone (GnRH) secretion, stimulating the hypothalamic-pituitary-gonadal axis.
  • Delayed puberty, often familial, is more common than hypogonadotropic hypogonadism, particularly in boys presenting with growth delay.
  • Hypogonadotropic hypogonadism can be congenital (genetic disorders) or acquired (hypothalamic-pituitary dysfunction, e.g., tumors).

Purpose of the Study:

  • To summarize the understanding of puberty regulation and the clinical presentation of delayed puberty and hypogonadotropic hypogonadism.
  • To outline treatment strategies for delayed puberty and hypogonadotropic hypogonadism.

Main Methods:

  • Review of the physiological mechanisms of puberty.
  • Discussion of clinical presentations and etiological factors of delayed puberty and hypogonadotropic hypogonadism.
  • Overview of therapeutic interventions.

Main Results:

  • Androgen therapy (3-6 months) can improve psychosocial well-being and induce growth and virilization in boys with delayed puberty.
  • Treatment of hypogonadotropic hypogonadism can involve pulsatile GnRH, gonadotropins, or sex steroids.
  • Sex steroids alone induce secondary sex characteristics, while combined GnRH and gonadotropin therapy can promote gonadal development and fertility.

Conclusions:

  • Delayed puberty and hypogonadotropic hypogonadism require tailored therapeutic approaches.
  • Hormone therapy can effectively manage these conditions, addressing both physical development and fertility concerns.
  • Understanding the GnRH-mediated regulation of puberty is crucial for effective clinical management.