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Cerebrum: Anatomical Overview II

Cerebrum: Anatomical Overview II

Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...

Cerebrum: Anatomical Overview I

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The main and largest component of the human brain is the cerebrum. The cerebrum consists of two main parts: the cerebral cortex, an outer layer with wrinkles or folds known as gyri and shallow grooves called sulci, and a deeper region beneath it. The cerebrum divides into two distinct hemispheres and contains five different lobes: the frontal, parietal, temporal, occipital, and insula. The central sulcus separates the frontal and parietal lobes and two functionally important gyri — the...

Anatomy of the Brain: Ventricles

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Related Experiment Video

Updated: Mar 19, 2026

Simultaneous Cryosectioning of Multiple Rodent Brains

Simultaneous Cryosectioning of Multiple Rodent Brains

Published on: September 18, 2018

Brain histology.

Alexander Jeans¹, Margaret Esiri

¹Neuropathology Department, Oxford Radcliffe NHS Trust, Oxford, UK.

Practical Neurology

|September 18, 2008

Summary

This summary is machine-generated.

This article reviews nervous system histology and staining techniques, including immunostains. Understanding these methods aids clinicians in interpreting neuropathology reports and appreciating the central nervous system

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Last Updated: Mar 19, 2026

Simultaneous Cryosectioning of Multiple Rodent Brains

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Published on: September 18, 2018

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans

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Utilizing 3D Printing Technology to Merge MRI with Histology: A Protocol for Brain Sectioning

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Published on: December 6, 2016

Area of Science:

Neuropathology
Histology
Neuroscience

Background:

Nervous system histology is crucial for understanding health and disease.
Traditional staining techniques have evolved significantly.
Immunostains represent a major advancement in neuropathology.

Purpose of the Study:

To summarize current knowledge of nervous system histology in health and disease.
To introduce recent developments in histological staining techniques, especially immunostains.
To enhance clinicians' understanding of neuropathology for improved report interpretation.

Main Methods:

Review of established and novel histological staining techniques.
Focus on the application and interpretation of immunostains.
Synthesis of information on microscopic structures of the central nervous system.

Main Results:

Detailed overview of nervous system histology in various conditions.
Explanation of the principles and utility of modern staining methods.
Demonstration of how staining techniques reveal microscopic CNS architecture.

Conclusions:

Familiarity with neuropathology staining is invaluable for clinicians.
Advanced techniques like immunostains improve diagnostic accuracy.
Understanding microscopic CNS structure enhances clinical interpretation and appreciation.