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Updated: Jun 30, 2026
09:18
A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
Published on: March 8, 2017
Issues, indications, and controversies regarding intratympanic steroid perfusion
1The Cleveland Hearing & Balance Center, Cleveland, Ohio 44122, USA. hamidma@ClevelandHearingBalance.com
Current Opinion in Otolaryngology & Head and Neck Surgery
|September 18, 2008
Summary
Intratympanic inner ear steroid perfusion (ITPs) is increasingly used for inner ear disorders but lacks robust clinical evidence. Further research is needed to confirm its efficacy, especially for Ménière's disease.
Area of Science:
- Otolaryngology
- Neurotology
- Inner Ear Therapeutics
Background:
- Office-based intratympanic inner ear steroid perfusion (ITPs) is a growing treatment for Ménière's disease, autoimmune inner ear disease, and sudden sensorineural hearing loss.
- Despite increased utilization, the efficacy and application of ITPs remain controversial within the otology and neurotology fields.
Purpose of the Study:
- To review the existing basic science and human studies concerning intratympanic inner ear steroid perfusion (ITPs) treatment.
Main Methods:
- Literature review of animal and human studies on ITPs.
- Examination of studies related to drug delivery, steroid type and concentration, and comparative analyses with natural disease progression.
Main Results:
- Animal studies address inner ear changes post-ITPs, but clinical data, particularly for Ménière's disease and sudden sensorineural hearing loss, is limited.
- There is a lack of consistent research on optimal drug delivery methods, steroid formulations, and comparisons to the natural history of Ménière's disease.
Conclusions:
- Intratympanic inner ear steroid perfusion (ITPs) has significantly influenced otologic practice.
- Establishing the long-term efficacy of ITPs for Ménière's disease, compared to its natural course, requires more rigorous basic science and clinical investigation.
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