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Related Experiment Video

Updated: Jun 30, 2026

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Design, Surface Treatment, Cellular Plating, and Culturing of Modular Neuronal Networks Composed of Functionally Inter-connected Circuits

Published on: April 15, 2015

Extracellular clusterin promotes neuronal network complexity in vitro.

Grzegorz Wicher¹, Asa Fex-Svenningsen, Isabel Velsecchi

¹Department of Neuroscience, Biomedical Centre, Uppsala University, Uppsala, Sweden. Grzegorz.Wicher@neuro.uu.se

|September 18, 2008

Summary

Clusterin (apolipoprotein J) promotes nerve cell survival and enhances neuronal network complexity. This secreted protein may also aid in neuronal process formation, elongation, and plasticity after neural injury.

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Last Updated: Jun 30, 2026

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Preparation of Neuronal Co-cultures with Single Cell Precision

Preparation of Neuronal Co-cultures with Single Cell Precision

Published on: May 20, 2014

Area of Science:

Neuroscience
Molecular Biology
Biochemistry

Background:

Clusterin (apolipoprotein J) is a conserved glycoprotein involved in various physiological and pathological processes.
Extracellular clusterin participates in lipid transport and cellular debris clearance.
Intracellular clusterin regulates signal transduction and is upregulated during cellular stress, potentially aiding nerve cell survival and neuroplasticity post-neural injury.

Purpose of the Study:

To investigate the role of extracellular clusterin in modulating neuronal network complexity in vitro.
To explore clusterin's potential influence on neuronal process formation and plasticity.

Main Methods:

Quantitative analysis of neuronal cultures treated with clusterin.
In vitro assessment of neuronal network complexity.

Main Results:

Clusterin-treated neuronal cultures exhibited significantly increased network complexity.
Evidence suggests clusterin promotes neuronal process formation and elongation.

Conclusions:

Extracellular clusterin enhances neuronal network complexity in vitro.
Beyond its neuroprotective functions, clusterin may play a role in neuronal plasticity, including process formation and elongation.