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Published on: January 17, 2018
[hGH treatment impact on adrenal and thyroid functions]
Manoel R A Martins1, Julio Abucham
1Serviço de Endocrinologia e Diabetes, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
Arquivos Brasileiros De Endocrinologia E Metabologia
|September 18, 2008
Summary
Growth hormone (GH) replacement impacts thyroid and adrenal function in patients with GH deficiency. It boosts active thyroid hormone (T3) levels while decreasing active cortisol levels, influencing hypopituitarism management.
Area of Science:
- Endocrinology
- Hormone Physiology
Context:
- Growth hormone (GH) deficiency affects multiple endocrine axes.
- Understanding GH's role in thyroid and adrenal hormone regulation is crucial.
Purpose:
- To review the effects of GH on the thyrotrophic and corticotrophic axes.
- To explore the mechanisms and clinical implications of these effects.
Summary:
- GH replacement increases the conversion of thyroxine (T4) to triiodothyronine (T3).
- GH replacement promotes the conversion of cortisol to cortisone, its inactive form.
- These actions are significant in managing hypopituitary patients.
Impact:
- Provides insights into managing hormone imbalances in hypopituitarism.
- Highlights the dual role of GH in thyroid hormone activation and cortisol inactivation.
- Informs clinical strategies for somatotrophic therapy.
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