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[Sedural toxicity].

R Kornowski1, M Averbuch, A Jaffe

  • 1Dept. of Medicine T, Ichilov Hospital and Sackler School of Medicine, Tel Aviv University.

Harefuah
|March 15, 1991
PubMed
Summary
This summary is machine-generated.

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Phenazopyridine, used for dysuria relief, can cause serious adverse effects. A case report details a young woman experiencing methemoglobinemia, acute kidney injury, and hemolytic anemia after a single dose.

Area of Science:

  • Pharmacology
  • Toxicology
  • Nephrology

Background:

  • Phenazopyridine is a common analgesic for urinary tract infections.
  • It is generally perceived as safe by healthcare professionals.
  • Physicians may be unaware of its potential toxicities.

Observation:

  • A 24-year-old female patient presented with severe adverse events.
  • The patient had taken a single 1-gram dose of phenazopyridine.
  • Symptoms included methemoglobinemia, acute renal failure, and hemolytic anemia.

Findings:

  • Phenazopyridine toxicity can manifest as severe hematological and renal complications.
  • This case highlights the potential for serious adverse drug reactions even with single-dose administration.
  • Methemoglobinemia, acute kidney injury, and hemolytic anemia are critical adverse events associated with phenazopyridine.

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Implications:

  • Clinicians should be aware of phenazopyridine's potential for severe toxicity.
  • Enhanced patient counseling regarding phenazopyridine risks is warranted.
  • Further research into phenazopyridine's adverse event profile and risk factors is recommended.