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Updated: Jun 30, 2026
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Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
Published on: February 27, 2011
Integrating mouse anatomy and pathology ontologies into a phenotyping database: tools for data capture and training
John P Sundberg1, Beth A Sundberg, Paul Schofield
1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609-1500, USA. john.sundberg@jax.org
Summary
The Mouse Disease Information System (MoDIS) aids mouse phenotyping by standardizing pathology data. It enables quantitative trait locus analyses and gene mapping through integrated ontologies and disease severity scoring.
Area of Science:
- * Mouse pathology and phenotyping research.
- * Biomedical informatics and data management.
Background:
- * Laboratory mouse studies require standardized pathology data capture for accurate phenotyping.
- * Existing systems may lack integration with semantic standards and quantitative analysis tools.
Purpose of the Study:
- * To introduce the Mouse Disease Information System (MoDIS) as a solution for mouse pathology data capture.
- * To facilitate standardized phenotyping and quantitative analysis in mouse models.
Main Methods:
- * Integration of Mouse Anatomy (MA) and Mouse Pathology (MPATH) ontologies.
- * Utilization of a Microsoft Access database for data management.
- * Implementation of disease severity grading for lesion scoring.
- * Direct linkage to the Pathbase online database for reference and image access.
Main Results:
- * MoDIS provides a structured system for coding mouse pathology data.
- * Disease severity scores are generated for quantitative trait locus (QTL) analyses and gene mapping.
- * Access to standardized disease definitions and photomicrographic images is available.
Conclusions:
- * MoDIS is a valuable, open-source tool for establishing mouse pathology phenotyping programs.
- * The system supports standardized data collection and analysis in mouse research.
- * MoDIS facilitates advanced genetic analyses through quantitative pathology data.
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