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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
Published on: July 18, 2013
Correlation between IL-10 gene expression and HPV infection in cervical cancer: a mechanism for immune response
Victor H Bermudez-Morales1, Lourdes X Gutierrez, Juan M Alcocer-Gonzalez
1Division of Molecular Biology of Pathogens, National Institute of Public Health, Morelos, Mexico.
Abstract:
The present study was performed to determine IL-10 expression in cervical tissues in Mexican women according to the severity of the malignity and its association with HPV infection. IL-10 expression showed a clear tendency to increase during the different cervical cancer stages: 37% in LGSIL; 62% in HGSIL; and 84% in cancer. However, all the patients that expressed IL-10 were HPV positives; we found an association with HPV 16. These results suggest a clear relationship between IL-10, HPV and the stage of cervical cancer disease; this event could contribute to the immunosuppressive micro-environment in the tumor site.
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