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[Vaginal ulcers in Behçet disease].
Fernando Mendoza Calderón1, Virgilio G Valladares, Alberto M Ballesteros
1Hospital Civil Fray Antonio Alcalde, Guadalajara, Jalisco, México.
Ginecologia Y Obstetricia De Mexico
|September 19, 2008
Summary
This case study highlights a rare instance of Behçet disease (BD) in Mexico, presenting with severe vascular and ulcerative symptoms. Early diagnosis and combined anticoagulant and corticosteroid therapy led to a positive patient outcome.
Area of Science:
- Vascular Medicine
- Rheumatology
- Dermatology
Background:
- Behçet disease (BD) is a rare multisystemic vasculitis with a low incidence in Mexico compared to the USA.
- The disease often presents with mucocutaneous lesions, but can involve major vessels.
Observation:
- A 30-year-old female presented with a history of vaginal ulcers since age 26, initially treated with antimicrobials.
- She later developed superior and inferior vena cava thrombosis, cervical vaginitis, and oral ulcers.
- A positive Pathergy test and biopsy confirmed chronic ulcerative and vascular damage.
Findings:
- The patient exhibited significant vascular complications including vena cava thrombosis.
- Despite initial treatment with azathioprine, her condition did not improve.
- A combination of anticoagulant therapy and corticosteroids resulted in a favorable clinical response.
Implications:
- This case underscores the importance of considering Behçet disease in patients with unexplained ulcerative and thrombotic events, even in low-prevalence regions.
- Aggressive management with anticoagulation and corticosteroids can be effective in managing severe vascular manifestations of BD.
- Further research is needed to understand the geographic variations in Behçet disease incidence and presentation.
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