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Updated: Jun 30, 2026
A Mouse Model for Laser-induced Choroidal Neovascularization
Published on: December 27, 2015
[Experimental choroidal neovascularization induced by laser in the eyes of rhesus monkeys]
1Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To establish an experimental model of choroidal neovascularization (CNV) through perimacular laser treatment in the eyes of rhesus Monkey.
Methods:
The experimental CNV was induced by perimacular laser injury in the eyes of 8 rhesus monkeys and confirmed by a comparison before and after the laser treatment (20 d, 34 d, 48 d) with fluorescence fundus angiography (FFA) and optical coherence tomography (OCT).
Results:
Classic CNV similar to human CNV appeared in 68.8% of the laser spots. Hypofluorescence in the early phase and fluorescence leakage in the late phase were detected by the FFA. High reflect light echogenic mass and retina edema were detected by the OCT. The histopathologic examinations found proliferated fiber-vasculosa membranes in the laser burnt spots. The pathological changes lasted 48 days until the monkeys were killed.
Conclusion:
The laser induced experimental CNV in rhesus monkey has a high prevalence and stability, which maintains a long period. It is an ideal experimental model for studying the pathologic mechanism of CNV and effective treatment for CNV.
