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Central auditory toxicity of sisomicin in guineapigs
T Khalique1, S A Hasan, M Hasan
1Department of Otorhinolaryngology, J.N. Medical College, Aligarh Muslim University.
The Indian Journal of Medical Research
|April 1, 1991
Abstract:
The central auditory toxicity of sisomicin was studied in guineapigs administered sisomicin (135 mg/kg body weight) sc for 10 days. Total lipids, phospholipids and cholesterol were estimated in the pons, inferior colliculus, medial geniculate body and auditory cortex. While the total lipids were increased in a non-preferential manner in all the regions studied, phospholipids and cholesterol levels registered no change. This study suggests the possible central auditory toxicity following sisomicin administration.