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Iloprost treatment for refractory Raynaud's phenomenon in two infants

D S Shouval1, M Mukamel, F Zulian

  • 1Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. dror_sho@netvision.net.il

Clinical and Experimental Rheumatology
|October 24, 2008
PubMed

Insights

Severe Raynaud

Area of Science:

  • Pediatric Rheumatology
  • Vascular Medicine
  • Neonatology

Background:

  • Raynaud's phenomenon (RP) is uncommon in pediatric populations.
  • Severe RP can lead to critical ischemia, including fingertip necrosis.

Purpose of the Study:

  • To report the successful use of iloprost in infants with severe, treatment-resistant Raynaud's phenomenon.
  • To evaluate the safety and efficacy of iloprost for critical digital ischemia in neonates.

Main Methods:

  • Case report of two infants with severe Raynaud's phenomenon and fingertip necrosis.
  • Treatment with iloprost, a prostacyclin analogue, after failure of conventional vasodilators.

Main Results:

  • Both infants showed successful resolution of ischemic symptoms and healing of necrotic digits with iloprost treatment.
  • Iloprost was well-tolerated, with no significant adverse events reported.

Conclusions:

  • Iloprost is a safe and effective treatment option for severe Raynaud's phenomenon with critical digital ischemia in infants.
  • Consider iloprost for pediatric patients presenting with threatening ischemic digits unresponsive to standard therapies.

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