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Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
Aneurysm I: Introduction01:30

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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
Aneurysm III: Interprofessional Care01:26

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Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

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Updated: Jun 30, 2026

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
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Aortic involvement in ankylosing spondylitis.

C Palazzi1, S D' Angelo, E Lubrano

  • 1Department of Internal Medicine, Villa Pini Clinic, Chieti, Italy.

Clinical and Experimental Rheumatology
|October 24, 2008
PubMed
Summary
This summary is machine-generated.

Ankylosing spondylitis (AS) patients frequently develop cardiovascular issues, primarily aortitis affecting the aorta and valves. Early recognition and treatment of these cardiac manifestations are crucial for managing AS progression.

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Area of Science:

  • Rheumatology
  • Cardiology
  • Immunology

Background:

  • Ankylosing spondylitis (AS) is a chronic inflammatory disease.
  • Cardiovascular manifestations are a significant concern in AS patients.
  • Aortitis is the most common cardiac complication.

Purpose of the Study:

  • To summarize the cardiovascular manifestations in ankylosing spondylitis.
  • To highlight the importance of early diagnosis and management of cardiac involvement in AS.

Main Methods:

  • Literature review of cardiovascular complications in AS.
  • Analysis of clinical presentations and pathological findings.
  • Discussion of diagnostic and therapeutic strategies.

Main Results:

  • Aortitis, particularly of the aortic root and ascending aorta, is the primary manifestation, leading to valvular insufficiency.
  • Conduction abnormalities due to subaortic fibrosis are the second most common cardiac issue.
  • Coronary artery and other aortic segment involvement are less frequent.

Conclusions:

  • Cardiovascular involvement, especially aortitis, is a serious complication of AS.
  • Prompt recognition and management by rheumatologists are essential for improving patient outcomes.
  • Continuous monitoring for cardiac manifestations is recommended throughout the disease course.