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Related Experiment Video

Updated: Jun 30, 2026

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Microfluidic Model of Necrotizing Enterocolitis Incorporating Human Neonatal Intestinal Enteroids and a Dysbiotic Microbiome

Published on: July 28, 2023

A roadmap for understanding and preventing necrotizing enterocolitis.

Josef Neu¹, Maka Mshvildadze, Volker Mai

¹1600 Southwest Archer Road, Gainesville, FL 32610, USA. neuj@peds.ufl.edu

Current Gastroenterology Reports

|September 19, 2008

Summary

This summary is machine-generated.

Necrotizing enterocolitis (NEC), a severe newborn gastrointestinal emergency, lacks a determined cause. New microbiome and metabolomic techniques may help diagnose and prevent this condition in at-risk infants.

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A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis

Published on: April 10, 2019

Area of Science:

Neonatal medicine
Gastroenterology
Microbiology

Background:

Necrotizing enterocolitis (NEC) is a critical gastrointestinal emergency in newborns.
The exact cause of NEC remains unknown, hindering effective prevention and treatment.
Current understanding relies on epidemiology, clinical observations, and animal models, which have limitations in representing human infant NEC.

Purpose of the Study:

To explore novel approaches for understanding the etiology of NEC.
To highlight the potential of advanced analytical techniques in NEC research.
To identify new avenues for early diagnosis and prevention of NEC.

Main Methods:

Review of existing knowledge on NEC pathogenesis.
Discussion of emerging analytic techniques, including microbiome analysis (e.g., Human Microbiome Roadmap Project).
Exploration of proteomic and metabolomic approaches.

Main Results:

An immature, bacteria-colonized intestine is essential for NEC development.
Advanced techniques can detect previously unculturable microbes and assess microbial diversity and function.
Proteomics and metabolomics show promise for NEC diagnostics and prevention.

Conclusions:

Understanding the gut microbiome's role is crucial for NEC research.
New technologies offer significant potential for advancing NEC diagnosis and prevention strategies.
Further research integrating microbiome, proteomic, and metabolomic data is warranted for at-risk infants.