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Updated: Jun 30, 2026

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Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
Published on: September 18, 2014
Synthesis and immunostimulatory properties of the phosphorothioate analogues of cdiGMP
Hongbin Yan1, Xiaolu Wang, Rhonda KuoLee
1Department of Chemistry, Brock University, 500 Glenridge Avenue, St. Catharines, Ont., Canada L2S 3A1. tyan@brocku.ca
Bioorganic & Medicinal Chemistry Letters
|September 19, 2008
Abstract:
The synthesis of mono- and bisphosphorothioate analogues of 3',5'-cyclic diguanylic acid (cdiGMP) via the modified H-phosphonate chemistry is reported. The immunostimulatory properties of these analogues were compared with those of cdiGMP.

