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Related Experiment Videos

Diet and bladder cancer in Spain: a multi-centre case-control study.

E Riboli1, C A González, G López-Abente

  • 1International Agency for Research on Cancer, Lyon, France.

International Journal of Cancer
|September 9, 1991
PubMed
Summary

High saturated fat intake significantly increases bladder cancer risk. This case-control study in Spain highlights dietary factors, particularly saturated fats, as potential influences on bladder cancer development.

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Area of Science:

  • Epidemiology
  • Nutritional Science
  • Oncology

Background:

  • Bladder cancer is a significant health concern globally.
  • Dietary patterns are increasingly recognized as modifiable risk factors for various cancers.
  • Understanding the specific role of dietary components in bladder cancer etiology is crucial for prevention strategies.

Purpose of the Study:

  • To investigate the association between dietary habits and bladder cancer risk in a Spanish population.
  • To identify specific food groups and nutrients that may influence the occurrence of bladder cancer.

Main Methods:

  • A multi-centre case-control study involving 432 male bladder cancer cases and 792 matched controls in Spain.
  • Dietary habits were assessed using an interview-based dietary history questionnaire.

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  • Statistical analyses adjusted for tobacco smoking and energy intake to determine relative risks (RR) for various dietary factors.

    • Main Results:

    • A significantly increased risk of bladder cancer was observed in subjects with the highest intake of saturated fat (RR = 2.25).
    • Moderate increases in risk were associated with high intake of monounsaturated fats and calcium, but these effects diminished after adjustment for saturated fat.
    • Intake of vitamin E showed a trend towards reduced risk (RR = 0.72), independent of fat intake.

    Conclusions:

    • Saturated fat intake appears to be a significant risk factor for bladder cancer.
    • Dietary modifications, particularly reducing saturated fat consumption, may play a role in bladder cancer prevention.
    • Further research is warranted to elucidate the complex interplay between diet and bladder cancer.