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Related Concept Videos

Urinary Tract Calculi I: Introduction01:28

Urinary Tract Calculi I: Introduction

Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Urinary Tract Calculi IV: Nutrition Therapy and Prevention01:27

Urinary Tract Calculi IV: Nutrition Therapy and Prevention

Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...

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Related Experiment Video

Updated: Jun 30, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

Elevated uric acid increases the risk for kidney disease.

Rudolf P Obermayr1, Christian Temml, Georg Gutjahr

  • 13rd Medical Department, Donauspital, Sozialmedizinisches Zentrum Ost der Stadt Wien, Langobardenstrasse 122, A-1220 Vienna, Austria (EU). rudolf.obermayr@gmail.com

Journal of the American Society of Nephrology : JASN
|September 19, 2008
PubMed
Summary

Elevated uric acid levels significantly predict new-onset kidney disease. This study found that higher uric acid concentrations independently increase the risk for developing kidney disease in healthy adults.

Related Experiment Videos

Last Updated: Jun 30, 2026

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril
10:02

Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril

Published on: October 3, 2020

Area of Science:

  • Nephrology
  • Epidemiology
  • Metabolic Syndrome

Background:

  • Epidemiologic studies suggest a link between uric acid and kidney disease development.
  • The independent role of uric acid as a risk factor for incident kidney disease requires further investigation.

Purpose of the Study:

  • To examine the association between serum uric acid levels and the incidence of kidney disease.
  • To determine if uric acid is an independent risk factor for new-onset kidney disease.

Main Methods:

  • Prospective analysis of data from 21,475 healthy volunteers followed for a median of 7 years.
  • Incident kidney disease defined as estimated glomerular filtration rate (eGFR) <60 ml/min per 1.73 m(2).
  • Statistical adjustments for baseline eGFR, demographics, antihypertensive use, and metabolic syndrome components.

Main Results:

  • A slightly elevated uric acid level (7.0-8.9 mg/dl) nearly doubled the risk of incident kidney disease (OR 1.74).
  • An elevated uric acid level (≥9.0 mg/dl) tripled the risk of incident kidney disease (OR 3.12).
  • Risk increased non-linearly with uric acid levels, with rapid acceleration above 6-8 mg/dl depending on sex, even after full adjustment.

Conclusions:

  • Elevated serum uric acid is an independent risk factor for new-onset kidney disease.
  • Uric acid levels show a dose-dependent relationship with kidney disease risk.
  • These findings highlight the importance of monitoring uric acid in kidney disease prevention strategies.