Related Experiment Video

Updated: Jun 30, 2026

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients
09:09

Single Nuclei Isolation from Coronary Endarterectomy Tissue of Coronary Artery Bypass Graft Patients

Published on: April 3, 2026

Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the

Alanna C Morrison1, Lance A Bare, May M Luke

  • 1Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA. Alanna.C.Morrison@uth.tmc.edu

Cerebrovascular Diseases (Basel, Switzerland)
|September 19, 2008
PubMed

Insights

Genetic factors may link coronary heart disease (CHD) and ischemic stroke. This study found specific single nucleotide polymorphisms (SNPs) associated with stroke risk in the Atherosclerosis Risk in Communities (ARIC) study.

Area of Science:

  • Genetics
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • Ischemic stroke and coronary heart disease (CHD) share common etiological factors.
  • Genetic predispositions may underlie this shared etiology.
  • Identifying shared genetic markers is crucial for understanding disease mechanisms.

Purpose of the Study:

  • To investigate the association between 51 single nucleotide polymorphisms (SNPs) previously linked to CHD and the risk of incident ischemic stroke.
  • To determine if genetic variants confer risk for ischemic stroke across different ethnicities.

Main Methods:

  • Utilized data from the multiethnic Atherosclerosis Risk in Communities (ARIC) cohort (14,215 individuals).
  • Identified 495 validated ischemic stroke events.
  • Employed Cox proportional hazards models, adjusting for age and gender, to assess SNP associations.

Main Results:

  • Three SNPs in Whites and two SNPs in Blacks were associated with incident stroke (p <= 0.05).
  • The rs11628722 polymorphism in SERPINA9 showed association with incident stroke in both Whites and Blacks.
  • This association remained significant after adjusting for traditional cardiovascular risk factors.

Conclusions:

  • Suggests that common genetic factors, including variants in SERPINA9, may contribute to the etiology of both ischemic stroke and CHD.
  • Highlights the potential role of SERPINA9 as a shared genetic risk factor.
  • Recommends further investigation of these shared genetic links in independent cohorts.

More Related Videos

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene07:00

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene

Published on: April 1, 2019

Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu01:29

Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu

Genetic variations significantly influence drug response through pharmacokinetics, receptor interactions, and biologic milieu modifications. Pharmacokinetic alterations impact drug metabolism and clearance, affecting efficacy and toxicity. Variants in drug-metabolizing enzymes, such as CYP2C9 and CYP2C19, alter drug activation and elimination. For example, CYP2C9 loss-of-function variants require lower warfarin doses to prevent excessive bleeding, while CYP2C19 variants reduce clopidogrel...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...