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Related Experiment Video

Updated: Jun 30, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

[Renal cell carcinoma].

Wataru Obara1, Tomoaki Fujioka

  • 1Dept. of Urology, Iwate Medical University School of Medicine, Morioka, Japan.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|September 19, 2008
PubMed
Summary

Molecular targeted therapies have revolutionized advanced renal cell carcinoma treatment, moving beyond older cytokine therapies. Future treatments will focus on personalized medicine for optimal patient outcomes.

Area of Science:

  • Oncology
  • Medical treatment of renal cell carcinoma

Background:

  • Cytokine therapies like interferon and interleukin-2 were traditional treatments for advanced renal cell carcinoma.
  • The advent of molecular targeted medicine has significantly transformed treatment paradigms.

Purpose of the Study:

  • To review the evolution of renal cell carcinoma treatment from cytokine therapies to molecular targeted medicine.
  • To highlight the current mainstream targets and emerging therapeutic pathways.

Main Methods:

  • Review of existing literature on advanced renal cell carcinoma treatments.
  • Analysis of the efficacy of vascular endothelial growth factor pathway inhibitors.
  • Examination of alternative molecular pathways and their targeted inhibitors.

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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

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Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

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Main Results:

  • Vascular endothelial growth factor (VEGF) and its receptor inhibitors are current mainstream treatments.
  • Inhibitors targeting alternative molecular pathways have demonstrated established efficacy.
  • The field anticipates the introduction of novel molecular targeted therapies.

Conclusions:

  • Molecular targeted medicine represents a significant advancement in treating advanced renal cell carcinoma.
  • Personalized medicine, tailored to individual patient conditions, is crucial for optimal treatment in renal cell carcinoma.
  • Continued research and development are expected to yield even more advanced therapeutic options.