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Updated: Jun 30, 2026

Isolation and Characterization of Neutrophils with Anti-Tumor Properties
Published on: June 19, 2015
New roles for mononuclear phagocytes in cancer biology
Paul T Jubinsky1, David S Dickens, Mary K Short
1Pediatric Hematology/Oncology and Developmental and Molecular Biology, Albert Einstein College of Medicine and Children's Hospital, Montefiore, Bronx, NY 10461, USA. pjubinsk@aecom.yu.edu
Abstract:
The primary focus in the pathogenesis and treatment of human malignancies has been the tumor cell. However, the biologic properties of a malignancy are not all intrinsically determined. Interactions between heterogeneous cell populations influence the growth and survival of both normal and malignant cells. Studies defining the origin of endothelial cells involved in tumor angiogenesis first demonstrated the contributions of normal cellular environment. Recently, the mononuclear phagocyte lineage has been found to have biologically and clinically significant tumor enhancing and tumor suppressive effects. This article reviews the multiple roles of mononuclear phagocytes in cancer biology. A companion manuscript (J Pediatr Hematol Oncol. 2008, in press) describes the targeting of these cells for therapeutic benefit. Incorporating these strategies into future childhood cancer protocols could be an innovative approach for improving patient outcome.
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