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Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Related Experiment Video

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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

Encoded and multiplexed surface plasmon resonance sensor platform.

Katja F Kastl1, Christopher R Lowe, Carl E Norman

  • 1Cambridge Research Laboratory, Toshiba Research Europe Limited, 208 Cambridge Science Park, Milton Road, Cambridge, UK.

Analytical Chemistry
|September 20, 2008
PubMed
Summary
This summary is machine-generated.

A novel sensor system uses coded microparticles and label-free detection to simultaneously study molecular interactions in real-time. This flexible approach enhances assay customization compared to traditional microarrays.

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Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
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Last Updated: Jun 30, 2026

Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets
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Multimodal Analytical Platform on a Multiplexed Surface Plasmon Resonance Imaging Chip for the Analysis of Extracellular Vesicle Subsets

Published on: March 17, 2023

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles
11:54

Microfluidic Platform with Multiplexed Electronic Detection for Spatial Tracking of Particles

Published on: March 13, 2017

Area of Science:

  • Biotechnology
  • Analytical Chemistry
  • Materials Science

Background:

  • Traditional microarrays have limitations in flexibility and customization for studying molecular interactions.
  • Label-free detection methods are crucial for real-time kinetic analysis.
  • Multiplexed assays require versatile platforms for diverse applications.

Purpose of the Study:

  • To develop a flexible sensor system for simultaneous, real-time analysis of molecular interactions.
  • To combine the benefits of coded microparticles and label-free detection.
  • To offer high assay conformability for end-users.

Main Methods:

  • Utilizing discretely functionalized, code-bearing microparticles.
  • Employing grating-coupled surface plasmon resonance for label-free detection.
  • Implementing a single multiplexed assay format.

Main Results:

  • Demonstrated simultaneous investigation of real-time binding kinetics for multiple molecular interactions.
  • Showcased the system's ability to accommodate various immobilization chemistries and surface preparation methods.
  • Achieved high assay conformability, surpassing fixed microarray limitations.

Conclusions:

  • The developed sensor system provides a flexible and powerful platform for multiplexed, real-time molecular interaction analysis.
  • This technology offers significant advantages in assay customization and adaptability.
  • It represents a notable advancement over conventional microarray systems for kinetic studies.