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Related Concept Videos

Pharmacokinetics: Drug–Drug Interactions01:25

Pharmacokinetics: Drug–Drug Interactions

Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
Drug toxicity: Drug–Drug Interaction01:30

Drug toxicity: Drug–Drug Interaction

Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...
Pharmacokinetics: Drug–Food and Drug–Viral Interactions01:26

Pharmacokinetics: Drug–Food and Drug–Viral Interactions

A drug interaction occurs when the concurrent use of another drug, food, or an external substance alters the pharmacological activity of a drug. This interaction can modify the action of the original drug, affecting its effectiveness and safety.Drug–food interactions are significant as they impact drug absorption, metabolism, and excretion. For example, grapefruit juice is a well-known disruptor of drug metabolism. It inhibits the cytochrome P450 3A4 enzyme, crucial for the metabolism of many...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Drug Toxicity: Risk factors01:24

Drug Toxicity: Risk factors

Adverse Drug Reactions (ADRs) are potential complications that arise during pharmacotherapy, influenced by multiple risk factors. Age plays a significant role; both neonates and the elderly are at heightened risk due to their respective immature and diminished metabolic and elimination processes. Gender also impacts ADRs, with females experiencing a 1.5 to 1.7-fold greater risk than males, which may be linked to pharmacokinetic, pharmacodynamic, and hormonal differences. Notably, neonates, the...
Combined Effects of Drugs: Antagonism01:30

Combined Effects of Drugs: Antagonism

The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...

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Related Experiment Video

Updated: Jun 30, 2026

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
11:07

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Published on: November 24, 2021

Drug interactions in dermatological practice.

H L Tey1, E L Tian, A W Tan

  • 1National Skin Center, Singapore. hltey@nsc.gov.sg

Clinical and Experimental Dermatology
|September 20, 2008
PubMed
Summary
This summary is machine-generated.

Dermatologists must be aware of drug interactions, which can be avoided unlike unpredictable adverse drug reactions. This review highlights key drug interactions in dermatology, including those with supplements and herbs.

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Area of Science:

  • Dermatology
  • Clinical Pharmacology

Background:

  • Systemic drug use in dermatology is rising.
  • Polypharmacy increases the risk of drug interactions for dermatologists.
  • Drug interactions are predictable and avoidable, unlike adverse drug reactions.

Purpose of the Study:

  • To review significant drug interactions encountered in dermatological practice.
  • To categorize drug interactions for better clinical management.
  • To raise awareness of potential interactions with health supplements, herbs, and food.

Main Methods:

  • Literature review of significant drug interactions in dermatology.
  • Categorization of interactions based on drug classes (antimicrobials, immunosuppressants, etc.).
  • Inclusion of interactions with alternative and complementary therapies.

Main Results:

  • Key drug classes frequently involved in interactions include antimicrobials, immunosuppressants, antimalarials, colchicine, retinoids, and psychiatric medications.
  • Commonly interacting drugs include ciclosporin, azole antifungals, erythromycin, sulfonamides, and rifampicin.
  • Interactions with health supplements, herbs, and food are also presented.

Conclusions:

  • Dermatologists need to be vigilant about potential drug interactions.
  • Understanding and managing drug interactions is crucial for patient safety in dermatology.
  • Awareness of interactions with non-conventional therapies is important due to their increasing use.