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Herniated Intervertebral Disc l: Introduction

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...

Degenerative Disc Disease ll: Pathophysiology

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...

Degenerative Disc Disease I: Introduction

Degenerative Disc Disease I: Introduction

Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...

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Related Experiment Video

Updated: Jun 30, 2026

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability

Published on: July 25, 2025

Spontaneously disappearing lumbar disc protrusion.

Shungu Ushewokunze¹, Naeem Abbas, Ronan Dardis

¹Department of Neurosurgery, University Hospital of Coventry and Warwickshire, Coventry.

The British Journal of General Practice : the Journal of the Royal College of General Practitioners

|September 20, 2008

Summary

Spontaneous regression of herniated lumbar discs can occur. A case study shows a patient’s disc prolapse completely disappeared, supporting conservative management for lumbar disc issues.

Related Experiment Videos

Last Updated: Jun 30, 2026

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability

Multilevel Oblique Lumbar Interbody Fusion in Degenerative Lumbar Disc Disease with Instability

Published on: July 25, 2025

Area of Science:

Orthopedics
Neurosurgery
Radiology

Background:

Herniated lumbar discs can cause significant pain and disability.
Conservative management is often the first line of treatment.
Spontaneous regression of disc herniation is a recognized but infrequent phenomenon.

Observation:

A 45-year-old patient presented with lumbar radiculopathy symptoms.
Follow-up imaging revealed complete disappearance of the lumbar disc prolapse.
The patient's radiculopathy symptoms resolved concurrently with disc regression.

Findings:

The case demonstrates complete spontaneous resolution of a herniated lumbar disc.
Clinical symptom resolution correlated with radiological evidence of disc disappearance.
This supports the natural history of certain lumbar disc herniations.

Implications:

This case reinforces the efficacy of conservative treatment for lumbar disc protrusions.
It highlights the potential for non-surgical management to lead to complete recovery.
Further research into the mechanisms of spontaneous disc regression is warranted.