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Related Concept Videos

Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
Bioplastics01:27

Bioplastics

Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
Step-Growth Polymerization: Overview01:03

Step-Growth Polymerization: Overview

Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
Polymer Classification: Architecture01:14

Polymer Classification: Architecture

Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
Free-Radical Chain Reaction and Polymerization of Alkenes02:35

Free-Radical Chain Reaction and Polymerization of Alkenes

The conversion of alkenes to macromolecules called polymers is a reaction of high commercial importance. The structure of the polymer is defined by a repeating unit, while the terminal groups are considered insignificant. The average degree of polymerization represents the number of repeating units in the polymer molecule and is denoted by the subscript n.

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Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
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Published on: March 8, 2019

Development of biodegradable crosslinked urethane-doped polyester elastomers.

Jagannath Dey1, Hao Xu, Jinhui Shen

  • 1Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA.

Biomaterials
|September 20, 2008
PubMed
Summary
This summary is machine-generated.

Researchers developed new biodegradable elastomers called crosslinked urethane-doped polyesters (CUPEs) that are soft, strong, and fully elastic. These advanced biomaterials offer improved mechanical properties and biocompatibility for tissue engineering applications.

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Last Updated: Jun 30, 2026

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
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Published on: March 8, 2019

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Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers

Published on: December 16, 2022

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Traditional polyester elastomers lack strength and become brittle with increased crosslinking.
  • Biodegradable polyurethanes exhibit permanent deformation in dynamic environments.
  • Developing soft, strong, and fully elastic biomaterials for tissue engineering remains a significant challenge.

Purpose of the Study:

  • To synthesize and evaluate a novel class of biodegradable elastomers, crosslinked urethane-doped polyesters (CUPEs).
  • To address the need for soft, strong, and elastic biomaterials with excellent recovery from deformation.
  • To explore CUPEs for potential applications in tissue engineering and other biomedical fields.

Main Methods:

  • Synthesis of crosslinked urethane-doped polyesters (CUPEs).
  • Comprehensive mechanical property testing, including tensile strength and elongation at break.
  • In vitro and in vivo biocompatibility assessments, including preliminary hemocompatibility evaluation.
  • Evaluation of degradation rates and control over mechanical properties via synthesis variables.

Main Results:

  • CUPEs exhibited high tensile strength (up to 41.07 MPa) and elongation at break (222.66%).
  • Tunable mechanical properties and degradation rates were achieved by adjusting synthesis parameters.
  • Demonstrated good in vitro and in vivo biocompatibility with reduced platelet activation compared to PLLA.
  • The polymers showed excellent elasticity with 100% recovery from deformation.

Conclusions:

  • CUPEs represent a new class of biodegradable elastomers that are soft, strong, and fully elastic.
  • These materials possess favorable mechanical properties, biocompatibility, and processability for soft tissue engineering.
  • CUPEs offer versatile solutions for the demanding requirements of tissue engineering and biomedical applications.