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Updated: Jun 30, 2026

Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection
Published on: September 14, 2019
Active invasion and/or encapsulation? A reappraisal of host-cell parasitism by Cryptosporidium
Hanna Borowski1, Peta L Clode, R C Andrew Thompson
1Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, WA 6150, Australia.
Abstract:
Host-cell invasion by Cryptosporidium is a complex process that requires many different factors derived from both the parasite and the host cell. However, the exact natures of the processes have yet to be resolved. Here, research on different components of the invasion process is put in context, and the sequence of events and pathways associated with the establishment of Cryptosporidium in its unique niche is clarified. In addition, initial parasite-host contact, host-cell invasion and host-cell responses are described. The roles of parasite and host-cell-derived components in the invasion process are examined, as is the question of whether Cryptosporidium actively invades cells and to what extent host-cell responses are involved.
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