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Early postnatal nutrition determines somatotropic function in mice.

Laurent Kappeler1, Carlos De Magalhaes Filho, Patricia Leneuve

  • 1Institut National de la Santé et de la Recherche Médicale, Centre De Recherche Saint Antoine, Paris, France. laurent.kappeler@inserm.fr

Endocrinology
|September 20, 2008
PubMed
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Early life nutrition significantly impacts growth and long-term health. Postnatal underfeeding or overfeeding in mice permanently altered body size and led to later-life metabolic issues and increased blood pressure.

Area of Science:

  • Developmental biology
  • Endocrinology
  • Nutritional science

Background:

  • Disease development is increasingly linked to early life nutrition.
  • Postnatal nutrient deprivation has limited recovery compared to intrauterine growth restriction.
  • Early nutrition may influence growth plasticity via the somatotropic axis.

Purpose of the Study:

  • To investigate how early postnatal nutrition (undernutrition and overfeeding) affects growth plasticity.
  • To examine the developmental control of the somatotropic hormone axis.
  • To identify long-term disease phenotypes resulting from early nutritional changes.

Main Methods:

  • Cross-fostering in mice to manipulate early postnatal nutrition.
  • Assessment of endocrine growth regulation (GH, IGF-I, GHRH).

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  • Evaluation of adult disease phenotypes including glucose tolerance and arterial blood pressure.

    • Main Results:

    • Early underfeeding delayed growth; overfeeding accelerated it, with permanent alterations in body size.
    • Coordinated changes in pituitary GH, plasma IGF-I, acid-labile subunit, and hypothalamic GHRH were observed.
    • Both nutritional extremes resulted in reduced glucose tolerance, altered insulin secretion/resistance, and increased arterial blood pressure in adulthood.

    Conclusions:

    • Early postnatal nutrition significantly influences somatotropic axis development and function.
    • Altered early nutrition leads to persistent metabolic abnormalities and vascular impairment.
    • IGF-I may play a role in modulating hypothalamic stimulation of somatotropic function during development.