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Voriconazole-induced photosensitivity

Anurag N Malani1, David M Aronoff

  • 1Division of Infectious Diseases, St. Joseph Mercy Hospital, 5333 McAuley Dr Suite 3106, Ypsilanti, MI 48197, USA. malanian@umich.edu

Clinical Medicine & Research
|September 20, 2008
PubMed

Insights

Voriconazole, an antifungal drug, can cause photosensitivity reactions, a specific skin issue. This case study shows that stopping voriconazole treatment resolved the photosensitivity in a patient with Candida parapsilosis endocarditis.

Area of Science:

  • Dermatology
  • Mycology
  • Pharmacology

Background:

  • Voriconazole is a broad-spectrum triazole antifungal medication.
  • It is used to treat serious fungal infections like invasive aspergillosis and candidiasis.
  • Adverse cutaneous reactions occur in less than 10% of patients, ranging from mild rashes to severe conditions.

Observation:

  • Photosensitivity is an uncommon but characteristic skin reaction to voriconazole.
  • This reaction is more frequently observed with chronic voriconazole administration.
  • The study presents a case of voriconazole-induced phototoxicity in a 50-year-old male patient.

Findings:

  • The patient had Candida parapsilosis endocarditis.
  • Voriconazole therapy was associated with phototoxic dermatitis.
  • Discontinuation of voriconazole led to the reversal of the photosensitivity reaction.

Implications:

  • This case highlights voriconazole-induced phototoxicity as a potential adverse drug reaction.
  • Awareness of this side effect is crucial for clinicians managing patients on voriconazole.
  • Prompt recognition and drug withdrawal can effectively manage voriconazole-related photosensitivity.

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