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Updated: Jun 30, 2026

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
The anterior cruciate ligament: a review of recent concepts
Abstract:
The anterior cruciate ligament (ACL) consists of a small anteromedial band and a larger posterolateral band. Recent findings have shown the ACL to play a major role in the function of the knee joint. The ACL prevents anterior luxation of the tibia, limits tibial rotation, and resists valgus and varus stress to the knee. The most common mechanism of ACL injury involves hyperextension of the knee with a rotational component. Diagnosis of an ACL lesion consists of an accurate history, clinical tests and often, arthroscopic investigation. Treatment of an ACL injury may consist solely of a rehabilitation program, may involve surgical intervention, or a combination of the two. Many surgical procedures both intra-articular and extra-articular, have been used in the past. The most successful approach at this time appears to be a combination of intra-articular and extra-articular procedures. A contemporary trend in rehabilitation following surgery is the use of graduated stages of treatment beginning immediately postsurgery and continuing through to full return to activity. J Orthop Sports Phys Ther 1986;8(3):110-122.
