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Related Concept Videos

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...
Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure01:16

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...

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Related Experiment Video

Updated: Jun 30, 2026

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting
03:40

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting

Published on: January 17, 2025

Emerging therapies for extracorporeal support.

Josée Bouchard1, Nitin Khosla, Ravindra L Mehta

  • 1University of California at San Diego, San Diego, CA 92103, USA.

Nephron. Physiology
|September 20, 2008
PubMed
Summary

Recent advancements in dialytic therapies offer new treatments for acute kidney injury, sepsis, heart failure, and liver failure by targeting specific disease mechanisms. Critical assessment of these evolving technologies and their clinical outcomes is essential.

Related Experiment Videos

Last Updated: Jun 30, 2026

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting
03:40

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting

Published on: January 17, 2025

Area of Science:

  • Nephrology and Critical Care Medicine
  • Extracorporeal Therapies
  • Cardiorenal and Hepatorenale Syndrome

Background:

  • Dialytic therapies have seen significant technological evolution over the past decade.
  • Emerging techniques are now applied beyond acute kidney injury to conditions like sepsis, heart failure, and liver failure.
  • New devices are designed to address the specific pathophysiological mechanisms of these critical illnesses.

Purpose of the Study:

  • To review the mechanisms, advantages, and limitations of advanced dialytic techniques.
  • To assess the current evidence on the impact of these therapies on major clinical outcomes.
  • To provide a perspective on the use of these technologies in resource-limited settings.

Main Methods:

  • Review of high-volume hemofiltration, coupled plasma filtration adsorption, cascade hemofiltration, and high permeability hemofiltration for sepsis.
  • Analysis of Molecular Adsorbents Recycling System (MARS) and Prometheus for liver failure.
  • Evaluation of simplified ultrafiltration machines for acute decompensated heart failure.

Main Results:

  • Sepsis therapies enhance removal of pro-inflammatory mediators.
  • Liver failure treatments facilitate elimination of albumin-bound toxins like bilirubin.
  • Ultrafiltration machines achieve negative fluid balance in heart failure patients.

Conclusions:

  • Advanced dialytic techniques offer targeted interventions for multiple critical conditions.
  • Evidence regarding clinical outcomes needs critical evaluation, especially in diverse resource settings.
  • A balanced perspective is required for the implementation of these evolving technologies.