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Updated: Jun 30, 2026

In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
Published on: September 28, 2017
The genetics of mammalian circadian order and disorder: implications for physiology and disease
Joseph S Takahashi1, Hee-Kyung Hong, Caroline H Ko
1Howard Hughes Medical Institute, Northwestern University, Evanston, Illinois 60208-3520, USA. j-takahashi@northwestern.edu
Abstract:
Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The genetic basis of circadian rhythms is well studied in model organisms and, more recently, studies of the genetic basis of circadian disorders has confirmed the conservation of key players in circadian biology from invertebrates to humans. In addition, important advances have been made in understanding how these molecules influence physiological functions in tissues throughout the body. Together, these studies set the scene for applying our knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.
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